sm"FISH"ing for Hedgehog.
نویسندگان
چکیده
Patched (Ptch) receptors are critical negative regulators of Hedgehog signaling, where Ptch1 loss causes basal cell carcinoma and Ptch1;Ptch2 loss disrupts skin and hair follicle development. Adolphe et al. use single molecule fluorescent in situ hybridization to show quantitatively that Ptch receptors create a Hedgehog signaling gradient that may specify hair follicle development.
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عنوان ژورنال:
- The Journal of investigative dermatology
دوره 137 1 شماره
صفحات -
تاریخ انتشار 2017